Atelier 248 - Utilisation des données génétiques issues du séquençage haut débit dans l’étude des maladies : méthodologie statistique et applications

Télécharger : Programme

Mercredi 27 septembre 2017 ◘ Wednesday September, 27th 2017

14:30-15:00 Reception of participants
15:00-15:30 Welcome and presentation by the organizers
SESSION I From Genome-Wide SNP-chip to NGS data
15:30-16:15 Early successes for monogenic diseases
Christel Depienne (Faculté de Médecine de Strasbourg, France)
16:15-17:00 Difficulties for complex diseases: the example of Alzheimer’s disease
Gaël Nicolas (Inserm UMR1245, Rouen, France)
17:00-17:30 Coffee break
17:30-18:15 Large-scale sequencing projects of the general population in France
Emmanuelle Génin, (Inserm U1078, Brest, France)
18:15-19:00 From WES to WGS in association testing
Richard Redon (Inserm U1087, Nantes, France)
19:30 Dinner

Jeudi 28 septembre 2017 ◘ Thursday September, 28th 2017

06:30-09:00 Breakfast
SESSION II Methodological developments and applications to unravel genes involved in diseases
09:00-09:45 Rare variant association tests
Aurélie Cobat (Inserm U1163, Paris, France)
09:45-10:30 GxG and GxE interaction analyses
Hugues Aschard (Institut Pasteur, Paris, France)
10:30-11:00 Coffee break
11:00-11:45 Integration of genomics, epigenomics and transcriptomics in complex Diseases
Kristel Van Steen (Université de Liège, Belgique)
11:45-12:30 Phenotype similarity regression for identifying the genetic determinants of rare diseases
Daniel Greene (MRC, Cambridge, United Kingdom)
12:30-14:00 Lunch
14:00-14:45 Causal inferences in genetic epidemiology
Andreas Ziegler (University of Lübeck, Germany)
SESSION III Bringing NGS data to the clinic
14:45-15:30 Stratified medicine, personalized medicine & precision medicine (outside oncology)
Patrick Bossuyt (University of Amsterdam, Netherlands)
15:30-16:15 Clinical trial designs for personalized medicine in oncology
Sumithra Mandrekar (Mayo Clinic, Rochester, USA)
16:15-16:45 Coffee Break
16:45-17:30 How to develop risk prediction tools for prognosis and treatment selection
Anne-Laure Boulesteix (LMU Munich, Germany)
17:30-18:15 Bionformatics for Gene signatures and molecular subtypes in colorectal cancer
Mauro Delorenzi (Université de Lausanne, Suisse)
19:30-20:15 Cocktail
20:15 Dinner

Vendredi 29 septembre 2017 ◘ Friday September, 29th 2017

06:30-09:00 Breakfast
SESSION IV Data sharing & Ethics
09:00-09:45 Global alliance genetics and other large-scale sharing projects: why sharing and how ?
Dominique Stoppa-Lyonnet (Institut Curie, Paris, France)
09:45-10:30 Protecting outsourced genetic data
Dalel Bouslimi (Telecom Bretagne, Brest, France)
10:30-11:00 Coffee Break
11:00-11:45 Sharing the methods but not the data
Olivier Delaneau (Université de Genève, Suisse)
11:45-12:30 Ethics and the regulation of genomics after the advent of NGS?
Catherine Bourgain (Cermes3, Villejuif, France)
12:30-14:00 Lunch
14:00 Departure

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