Atelier 244 - Défis méthodologiques pour la surveillance des médicaments

Télécharger : Programme

Mercredi 8 mars 2017 ◘ Wednesday March, 8th 2017

15:30-16:00 Reception of participants
16:00-16:15 Welcome and presentation by the organizers

SESSION I Design of pharmacoepidemiological studies


Case-control studies: definition of cases, choice of controls

Joan-Ramon Laporte (Universitat Autònoma de Barcelona, Spain)


Example: Vaccines and auto-immune disease, PGRx

Lamiae Grimaldi (Laser, Paris, France)

17:30-18:00 Coffee break

Cohort and nested case-control studies Example 1: Benzodiazepines and dementia, PAQUID cohort

Sophie Billioti de Gage (ANSM, Saint-Denis, France)


Example 2: Menopausal hormone treatments, E3N cohort

Agnès Fournier (Inserm U1018, Villejuif, France)

19:30 Dinner

Jeudi 9 mars 2017 ◘ Thursday March, 9th 2017

06:30-08:30 Breakfast

Case-population studies

Bruno Stricker (Erasmus MC, Rotterdam, NL)


Example: Nonsteroidal anti-inflammatory drugs and liver transplant, SALT

Nicholas Moore (Inserm U1219, Université de Bordeaux, France)


Case series (application example in session II)

Heather Whitaker (Open University, Milton Keynes, UK)

10:30-11:00 Coffee break

SESSION II Use of existing medicoadministrative databases


Spontaneous reports: principle, interest, limitations

Bernard Bégaud (Inserm U1219, Université de Bordeaux, France)


Example of case series applied to spontaneous reports: Rotavirus vaccination and intussusception

Sylvie Escolano (Inserm U1181, Villejuif, France)


French national health insurance system database: what’s new, available data and limitations

Jérémie Rudant (CNAMTS, Paris, France)

12:45-14:00 Lunch

Example: Brand-name to generic substitution of antiepileptic drugs does not lead to loss of seizure control: A population-based case-crossover study

Emmanuel Oger (CHU et Université, Rennes, France)


Multiple database studies: opportunities and challenges for drug postmarketing surveillance

Gianluco Trifirò (Università degli Studi di Messina, Italy - Erasmus MC, Rotterdam, NL)

15:30-16:00 Coffee Break

SESSION III Methodological challenges in risk assessment


Time-related biases

Samy Suissa (McGill University, Montreal, Canada)


Modelling effects of time-varying exposures in time-to-event analyses

Michal Abrahamowicz (McGill University, Montreal, Canada)


Propensity scores and unmeasured confounding

John Seeger (Harvard School of Public Health, Boston, USA)

19:30-20:15 Cocktail
20:15 Dinner

Vendredi 10 mars 2017 ◘ Friday March, 10th 2017

06:30-08:30 Breakfast

SESSION IV Taking risk into account when making public health decision


Synthesis of published data: good practice of meta-analyses

Catherine Hill (Institut Gustave Roussy, Villejuif, France)


Individual causality versus populational causality

Jacques Bénichou (Inserm U1219, Université et CHU de Rouen, France)

10:00-10:30 Coffee Break

Politico-historical account of hepatitis B vaccine and multiple sclerosis

Annick Opinel (Institut Pasteur/Inserm U1181, Paris, France)

11:15-12:15 Round table: Impact of pharmacoepidemiological studies on public health decision
12:15-14:00 Lunch
14:00 Departure

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