Workshop 245 - Enhancer structure and function

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Mercredi 19 avril 2017 ◘ Wednesday April, 19th 2017

15:30-16:00 Reception of participants
16:00-16:15 Welcome and presentation by the organizers
16:15-17:00

Keynote: State of the art to study enhancer function in 3D

Frank Grosveld (Erasmus University, Rotterdam, The Netherlands)

SESSION I Enhancer function during normal development

17:00-17:45

Genetic dissection of α-globin enhancers in vivo

Douglas Higgs (Weatherall Institute of Molecular Medicine, Oxford, UK)

17:45-18:15 Coffee break
18:15-19:00

In vivo approaches to study distal regulatory elements of immunoglobulin loci

Eric Pinaud (CBRS, Limoge, France)

19:00-19:45

Long range interactions during erythroid differentiation

Eric Soler (IGMM, Montpellier, France)

20:00 Dinner

Jeudi 20 avril 2017 ◘ Thursday April, 20th 2017

06:30-09:00 Breakfast

SESSION II Chromatin signatures associated with enhancers

09:00-09:45

Transcription of enhancer elements

Gioacchino Natoli (IFOM-IEO, Milan, Italy)

09:45-10:30

Cell-type-specific control of enhancer activity

Simona Saccani (IRCAN, Nice, France)

10:30-11:00 Coffee break
11:00-11:45

Functional and topological characterization of pluripotency-associated poised enhancers

Alvaro Rada Iglesias (CMMC, Cologne, Germany)

11:45-12:30

Transcription initiation platforms at tissue-specific enhancers

Jean-Christophe Andrau (IGMM, Montpellier, France)

12:30-14:00 Lunch

SESSION III Enhancer deregulation in diseases

14:00-14:45

Oncogenic enhancers in acute myeloid leukemia

Ruud Delwel (Erasmus University, Rotterdam, The Netherlands)

14:45-15:30

Long range regulation of the sonic hedgehog gene in normal development and disease

Robert Hill (MRC Human Genetics Unit, Edinburgh, UK)

15:30-16:15

Non-coding genome function and diabetes

Jorge Ferrer (Imperial College London, UK)

16:15-16:45 Coffee Break
16:45-17:30

Non coding variations in disease

Stefan Mundlos (Max Planck Institute for Molecular Genetics, Berlin, Germany)

17:30-18:15

Enhancer deregulation in leukemia

Constanze Bonifer (University of Birmingham, UK)

19:30-20:15 Cocktail
20:15 Dinner

Vendredi 21 avril 2017 ◘ Friday April, 21st 2017

06:30-09:00 Breakfast

SESSION IV Experimental and bioinformatics tools to study enhancers genome-wide

09:00-09:45

Enhancer evolution across mammalian species

Duncan T. Odom (WTSI, Cambridge, UK)

09:45-10:30

Role of genetic variation on enhancer function

Bart Deplancke (EPFL, Lausanne, Switzerland)

10:30-11:00 Coffee Break
11:00-11:45

Assessment of enhancer activity by high-throughput reporter assays

Salvatore Spicuglia (TAGC, Marseille, France)

11:45-12:30

Bioinformatics analyses of cis-regulatory elements

Morgane Thomas-Chollier (IBENS, Paris, France)

12:30-14:00 Lunch
14:00 Departure

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